Description
Insulin-like Growth Factor-1 Long Arg3 (IGF-1 LR3) is a synthetic analog of human IGF-1 designed with a modified amino acid sequence to improve stability and extend half-life. It differs from native IGF-1 by the substitution of arginine for glutamic acid at position 3, along with an additional 13-amino-acid extension at the N-terminus. These modifications reduce binding affinity to IGF-binding proteins (IGFBPs), which normally sequester circulating IGF-1, thereby increasing bioavailability in experimental models.
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