Description
Melanotan II (MT-II) is a synthetic analog of the endogenous melanocortin peptide α-MSH, developed to investigate melanocortin receptor–mediated effects on pigmentation, metabolism, and sexual function. It shows activity at multiple receptor subtypes, including MC1R, MC3R, MC4R, and MC5R, where it may influence melanin production, inflammatory pathways, and energy balance. MT-II is a cyclic heptapeptide engineered to mimic α-MSH while offering improved molecular stability and resistance to enzymatic breakdown. Research has examined its ability to stimulate melanogenesis and modulate hypothalamic signaling tied to appetite and sexual behavior.


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